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Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies.

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Title: Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies.
Authors: Labrie M; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu., Li A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Creason A; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Betts C; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Keck J; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA., Johnson B; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Sivagnanam S; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Boniface C; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Ma H; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Blucher A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Chang YH; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Chin K; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Vuky J; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Guimaraes AR; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA., Downey M; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA., Lim JY; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Gao L; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Siex K; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Parmar S; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Kolodzie A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA., Spellman PT; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Goecks J; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Coussens LM; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Corless CL; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Pathology, Oregon Health and Science University, Portland, OR, USA., Bergan R; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Gray JW; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Mills GB; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mitri ZI; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. mitri@ohsu.edu.
Source: NPJ precision oncology [NPJ Precis Oncol] 2021 Oct 19; Vol. 5 (1), pp. 92. Date of Electronic Publication: 2021 Oct 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies.
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  Data: <searchLink fieldCode="AU" term="%22Labrie+M%22">Labrie M</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Creason+A%22">Creason A</searchLink>; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Betts+C%22">Betts C</searchLink>; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Keck+J%22">Keck J</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+B%22">Johnson B</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Sivagnanam+S%22">Sivagnanam S</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Boniface+C%22">Boniface C</searchLink>; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Blucher+A%22">Blucher A</searchLink>; 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Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Downey+M%22">Downey M</searchLink>; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Lim+JY%22">Lim JY</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Siex+K%22">Siex K</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Parmar+S%22">Parmar S</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Kolodzie+A%22">Kolodzie A</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Spellman+PT%22">Spellman PT</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Goecks+J%22">Goecks J</searchLink>; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Coussens+LM%22">Coussens LM</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Corless+CL%22">Corless CL</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Pathology, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Bergan+R%22">Bergan R</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Gray+JW%22">Gray JW</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Mills+GB%22">Mills GB</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Mitri+ZI%22">Mitri ZI</searchLink>; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. mitri@ohsu.edu.
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