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Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.

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Title: Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
Authors: Tosca EM; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, Università degli Studi di Pavia, Pavia, Italy., Gauderat G; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France., Fouliard S; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France., Burbridge M; Center for Therapeutic Innovation in Oncology, Servier, Suresnes, France., Chenel M; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France., Magni P; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, Università degli Studi di Pavia, Pavia, Italy.
Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Nov; Vol. 10 (11), pp. 1396-1411. Date of Electronic Publication: 2021 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
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  Data: <searchLink fieldCode="AU" term="%22Tosca+EM%22">Tosca EM</searchLink>; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, Università degli Studi di Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Gauderat+G%22">Gauderat G</searchLink>; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Fouliard+S%22">Fouliard S</searchLink>; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Burbridge+M%22">Burbridge M</searchLink>; Center for Therapeutic Innovation in Oncology, Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Chenel+M%22">Chenel M</searchLink>; Clinical Pharmacokinetics and Pharmacometrics Division, Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Magni+P%22">Magni P</searchLink>; Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology, Department of Electrical, Computer and Biomedical Engineering, Università degli Studi di Pavia, Pavia, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101580011%22">CPT: pharmacometrics & systems pharmacology</searchLink> [CPT Pharmacometrics Syst Pharmacol] 2021 Nov; Vol. 10 (11), pp. 1396-1411. <i>Date of Electronic Publication: </i>2021 Oct 28.
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      – TitleFull: Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
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