p21 produces a bioactive secretome that places stressed cells under immunosurveillance.

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Title: p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Authors: Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands., Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Sine CC; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., van Deursen EJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Hamada N; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Grasic J; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Friedman D; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Stutchman JT; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Can I; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Hamada M; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Lim DY; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Lee JH; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Ordog T; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Laberge RM; Unity Biotechnology, South San Francisco, CA 94080, USA., Shapiro V; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Source: Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. eabb3420. Date of Electronic Publication: 2021 Oct 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.abb3420