Measurement Biases Distort Cell-Free DNA Fragmentation Profiles and Define the Sensitivity of Metagenomic Cell-Free DNA Sequencing Assays.

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Title: Measurement Biases Distort Cell-Free DNA Fragmentation Profiles and Define the Sensitivity of Metagenomic Cell-Free DNA Sequencing Assays.
Authors: Chang A; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Mzava O; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Lenz JS; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Cheng AP; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Burnham P; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA., Motley ST; Global Good Fund, Intellectual Ventures Lab, Bellevue, WA, USA., Bennett C; Global Good Fund, Intellectual Ventures Lab, Bellevue, WA, USA., Connelly JT; Global Health Labs, Bellevue, WA, USA., Dadhania DM; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Transplantation Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA., Suthanthiran M; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Transplantation Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA., Lee JR; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Transplantation Medicine, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA., Steadman A; Global Health Labs, Bellevue, WA, USA., De Vlaminck I; Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Source: Clinical chemistry [Clin Chem] 2021 Dec 30; Vol. 68 (1), pp. 163-171.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9421549 Publication Model: Print Cited Medium: Internet ISSN: 1530-8561 (Electronic) Linking ISSN: 00099147 NLM ISO Abbreviation: Clin Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1530-8561
DOI:10.1093/clinchem/hvab142