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Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.

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Title: Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Authors: Cai S; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Moutal A; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Yu J; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Chew LA; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Isensee J; Department of Anesthesiology and Intensive Care Medicine, Translational Pain Research, University Hospital of Cologne, University Cologne, Joseph-Stelzmann-Str 9, Cologne D-50931, Germany., Chawla R; BIO5 Institute, 1657 East Helen Street, Tucson, AZ 85721, USA., Gomez K; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Luo S; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Zhou Y; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Chefdeville A; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Madura C; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Perez-Miller S; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.; Center for Innovation in Brain Sciences, University of Arizona, Tucson, AZ 85721, USA., Bellampalli SS; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Dorame A; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Scott DD; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., François-Moutal L; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Shan Z; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA., Woodward T; Department of Psychological and Brain Sciences, Program in Neuroscience and Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405-2204, USA., Gokhale V; BIO5 Institute, 1657 East Helen Street, Tucson, AZ 85721, USA.; College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA., Hohmann AG; Department of Psychological and Brain Sciences, Program in Neuroscience and Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405-2204, USA., Vanderah TW; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.; Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, AZ 85724, USA., Patek M; Regulonix LLC, 1555 E. Entrada Segunda, Tucson, AZ 85718, USA.; Bright Rock Path LLC, Tucson, AZ 85724, USA., Khanna M; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.; BIO5 Institute, 1657 East Helen Street, Tucson, AZ 85721, USA.; Center for Innovation in Brain Sciences, University of Arizona, Tucson, AZ 85721, USA.; Regulonix LLC, 1555 E. Entrada Segunda, Tucson, AZ 85718, USA., Hucho T; Department of Anesthesiology and Intensive Care Medicine, Translational Pain Research, University Hospital of Cologne, University Cologne, Joseph-Stelzmann-Str 9, Cologne D-50931, Germany., Khanna R; Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.; BIO5 Institute, 1657 East Helen Street, Tucson, AZ 85721, USA.; Center for Innovation in Brain Sciences, University of Arizona, Tucson, AZ 85721, USA.; Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, AZ 85724, USA.; Regulonix LLC, 1555 E. Entrada Segunda, Tucson, AZ 85718, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Nov 10; Vol. 13 (619), pp. eabh1314. Date of Electronic Publication: 2021 Nov 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
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