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An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.

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Title: An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
Authors: Nanishi E; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Borriello F; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA., O'Meara TR; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., McGrath ME; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Saito Y; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., Haupt RE; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., van Haren SD; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Cavazzoni CB; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Brook B; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Barman S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Chen J; Research Computing Group, Boston Children's Hospital, Boston, MA 02115, USA., Diray-Arce J; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Doss-Gollin S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., De Leon M; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., Prevost-Reilly A; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., Chew K; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., Menon M; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Xu AZ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Caradonna TM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA., Sherman AC; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Baden LR; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Ernst RK; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA., Dillen C; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Weston SM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Johnson RM; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Hammond HL; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Mayer R; Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA., Burke A; Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA., Bottazzi ME; Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, TX 77030, USA.; National School of Tropical Medicine and Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Hotez PJ; Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, TX 77030, USA.; National School of Tropical Medicine and Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Strych U; Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, TX 77030, USA.; National School of Tropical Medicine and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Chang A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Sage PT; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Zanoni I; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA., Ozonoff A; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA., Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dowling DJ; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Jan 26; Vol. 14 (629), pp. eabj5305. Date of Electronic Publication: 2022 Jan 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
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