Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
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| Title: | Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states. |
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| Authors: | Triana S; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Collaboration for Joint PhD degree between European Molecular Biology Laboratory and Heidelberg University, Faculty of Biosciences, Heidelberg, Germany.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Vonficht D; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Jopp-Saile L; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Berlin Institute of Health (BIH), Charité Universitätsmedizin Berlin, Berlin, Germany.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin, Germany., Raffel S; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Lutz R; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Leonce D; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Antes M; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Hernández-Malmierca P; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Ordoñez-Rueda D; Flow Cytometry Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Ramasz B; Flow Cytometry Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Boch T; Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Jann JC; Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Nowak D; Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Hofmann WK; Department of Hematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Müller-Tidow C; Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany., Hübschmann D; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Computational Oncology, Molecular Diagnostics Program, National Center for Tumor diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pediatric Immunology, Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany., Alexandrov T; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA., Benes V; Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany., Paulsen M; Flow Cytometry Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.; Novo Nordisk Foundation Center for Stem Cell Biology, DanStem. Faculty of Health and Medical Sciences Blegdamsvej, Copenhagen, Denmark., Velten L; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. lars.velten@crg.eu.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. lars.velten@crg.eu., Haas S; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany. simon.haas@bih-charite.de.; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany. simon.haas@bih-charite.de.; Berlin Institute of Health (BIH), Charité Universitätsmedizin Berlin, Berlin, Germany. simon.haas@bih-charite.de.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin, Germany. simon.haas@bih-charite.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. simon.haas@bih-charite.de.; Charité-Universitätsmedizin, Berlin, Germany. simon.haas@bih-charite.de. |
| Source: | Nature immunology [Nat Immunol] 2021 Dec; Vol. 22 (12), pp. 1577-1589. Date of Electronic Publication: 2021 Nov 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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