Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.

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Title: Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Authors: Kummer MP; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany., Ising C; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Kummer C; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany., Sarlus H; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Griep A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Vieira-Saecker A; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany., Schwartz S; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany., Halle A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Brückner M; Caesar Research Center, Bonn, Germany., Händler K; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and University of Bonn, Bonn, Germany., Schultze JL; Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and University of Bonn, Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Beyer M; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE) and University of Bonn, Bonn, Germany.; Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Latz E; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute of Innate Immunity, University of Bonn, Bonn, Germany.; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA., Heneka MT; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Faculty, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
Source: The EMBO journal [EMBO J] 2021 Dec 15; Vol. 40 (24), pp. e108662. Date of Electronic Publication: 2021 Nov 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2075
DOI:10.15252/embj.2021108662