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Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.

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Title: Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.
Authors: Chuckran CA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Cillo AR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Moskovitz J; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Overacre-Delgoffe A; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Somasundaram AS; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Shan F; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Integrative Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Magnon GC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Kunning SR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Abecassis I; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Zureikat AH; Department of Surgery, Division of Surgical Oncology, UPMC Hillman Cancer Center and UPMC Pancreatic Cancer Program, Pittsburgh, PA 15213, USA., Luketich J; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Pennathur A; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Sembrat J; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Rojas M; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Merrick DT; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Taylor SE; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Orr B; Department Obstetrics and Gynecology, Gynecologic Oncology Division, Medical University of South Carolina, Charleston, SC 29425, USA., Modugno F; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Women's Cancer Research Center, Magee-Women's Research Institute and Foundation and Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA., Buckanovich R; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Schoen RE; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Kim S; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Duvvuri U; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Zeh H; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, TX 75390, USA., Edwards R; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Kirkwood JM; Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Coffman L; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Ferris RL; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA., Vignali DAA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Source: Science translational medicine [Sci Transl Med] 2021 Dec 08; Vol. 13 (623), pp. eabf8495. Date of Electronic Publication: 2021 Dec 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prevalence of intratumoral regulatory T cells expressing neuropilin-1 is associated with poorer outcomes in patients with cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chuckran+CA%22">Chuckran CA</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, 200 Lothrop St., Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Cillo+AR%22">Cillo AR</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Moskovitz+J%22">Moskovitz J</searchLink>; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Overacre-Delgoffe+A%22">Overacre-Delgoffe A</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Somasundaram+AS%22">Somasundaram AS</searchLink>; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Shan+F%22">Shan F</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Integrative Systems Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.<br /><searchLink fieldCode="AU" term="%22Magnon+GC%22">Magnon GC</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Kunning+SR%22">Kunning SR</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Abecassis+I%22">Abecassis I</searchLink>; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Zureikat+AH%22">Zureikat AH</searchLink>; Department of Surgery, Division of Surgical Oncology, UPMC Hillman Cancer Center and UPMC Pancreatic Cancer Program, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Luketich+J%22">Luketich J</searchLink>; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Pennathur+A%22">Pennathur A</searchLink>; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Sembrat+J%22">Sembrat J</searchLink>; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Rojas+M%22">Rojas M</searchLink>; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Merrick+DT%22">Merrick DT</searchLink>; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+SE%22">Taylor SE</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Orr+B%22">Orr B</searchLink>; Department Obstetrics and Gynecology, Gynecologic Oncology Division, Medical University of South Carolina, Charleston, SC 29425, USA.<br /><searchLink fieldCode="AU" term="%22Modugno+F%22">Modugno F</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Women's Cancer Research Center, Magee-Women's Research Institute and Foundation and Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Buckanovich+R%22">Buckanovich R</searchLink>; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Schoen+RE%22">Schoen RE</searchLink>; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Duvvuri+U%22">Duvvuri U</searchLink>; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Zeh+H%22">Zeh H</searchLink>; Harold C. Simmons Comprehensive Cancer Center, UT Southwestern, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+R%22">Edwards R</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Kirkwood+JM%22">Kirkwood JM</searchLink>; Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Coffman+L%22">Coffman L</searchLink>; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Ferris+RL%22">Ferris RL</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Bruno+TC%22">Bruno TC</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Vignali+DAA%22">Vignali DAA</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
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