Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.

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Title: Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
Authors: Tin A; Department of Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USA. atin@umc.edu.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. atin@umc.edu., Schlosser P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Matias-Garcia PR; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; TUM School of Medicine, Technical University of Munich, Munich, Germany., Thio CHL; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Joehanes R; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Liu H; Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104, PA, USA., Yu Z; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Weihs A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Hoppmann A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Grundner-Culemann F; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kuhns VLH; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA., Adeyemo AA; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Agyemang C; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands., Ärnlöv J; Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden.; School of Health and Social Studies, Dalarna University, Falun, Sweden., Aziz NA; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany., Baccarelli A; Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA., Bochud M; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland., Brenner H; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bressler J; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA., Breteler MMB; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany., Carmeli C; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; Population Health Laboratory, University of Fribourg, Fribourg, Switzerland., Chaker L; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Corre T; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, 39216, MS, USA., Cox SR; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Eckardt KU; Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany., Ekici AB; Institute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg, 91054, Erlangen, Germany., Endlich K; Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Floyd JS; Department of Medicine, University of Washington, Seattle, 98101, WA, USA.; Department of Epidemiology, University of Washington, Seattle, 98101, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, 98101, WA, USA., Fraszczyk E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Gao X; Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA.; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China., Gào X; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany., Gelber AC; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ghasemi S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Gieger C; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany., Greenland P; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030, TX, USA., Harris SE; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Henneman P; Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands., Herder C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research, Munich-Neuherberg, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90095, CA, USA.; Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hurme MA; Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Hwang SJ; Framingham Heart Study, Framingham, MA, USA.; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA., Kasela S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK., Kronenberg F; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Kühnel B; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany., Ladd-Acosta C; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Liu D; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany., Lloyd-Jones DM; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Lorkowski S; Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany.; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany., Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90095, CA, USA., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK., Meeks KAC; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mishra PP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Nauck M; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nowak C; Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; Ludwig-Maximilians Universität München, Munich, Germany., Prokisch H; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Department of Computational Health, Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany., Psaty BM; Department of Medicine, University of Washington, Seattle, 98101, WA, USA.; Department of Epidemiology, University of Washington, Seattle, 98101, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, 98101, WA, USA.; Department of Health Services, University of Washington, Seattle, 98101, WA, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Ratliff SM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, 98101, WA, USA., Schöttker B; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany., Schwartz J; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Sedaghat S; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Sotoodehnia N; Cardiovascular Health Research Unit, University of Washington, Seattle, 98101, WA, USA., Stocker HR; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany., Stringhini S; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland., Sundström J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia., Swenson BR; Cardiovascular Health Research Unit, University of Washington, Seattle, 98101, WA, USA.; Institute for Public Health Genetics, University of Washington, Seattle, WA, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Venema A; Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands., Völker U; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Winkelmann J; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.; Chair Neurogenetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48109, MI, USA., Zheng Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Loh M; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Bavaria, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany., Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Akilesh S; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Woodward OM; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA., Susztak K; Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104, PA, USA., Teumer A; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland., Köttgen A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.
Corporate Authors: Estonian Biobank Research Team, Genetics of DNA Methylation Consortium
Source: Nature communications [Nat Commun] 2021 Dec 09; Vol. 12 (1), pp. 7173. Date of Electronic Publication: 2021 Dec 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-021-27198-4