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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.

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Title: Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.
Authors: Martín-de-Saavedra MD; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Dos Santos M; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Culotta L; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Varea O; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Spielman BP; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Parnell E; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Forrest MP; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Gao R; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Yoon S; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., McCoig E; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Jalloul HA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Myczek K; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Khalatyan N; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Hall EA; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Turk LS; Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA., Sanz-Clemente A; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Comoletti D; Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA; Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA; School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Department of Neuroproteomics, School of Medicine, Klinikum rechts der Isar, and Institute for Advanced Study, Technical University of Munich, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Burgdorf JS; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Barbolina MV; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Savas JN; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Penzes P; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: p-penzes@northwestern.edu.
Source: Neuron [Neuron] 2022 Feb 16; Vol. 110 (4), pp. 627-643.e9. Date of Electronic Publication: 2021 Dec 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca<superscript>2+</superscript> homeostasis and network synchrony via PMCA2/ATP2B2.
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  Data: <searchLink fieldCode="AU" term="%22Martín-de-Saavedra+MD%22">Martín-de-Saavedra MD</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+M%22">Dos Santos M</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Culotta+L%22">Culotta L</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Varea+O%22">Varea O</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Spielman+BP%22">Spielman BP</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Parnell+E%22">Parnell E</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Forrest+MP%22">Forrest MP</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Gao+R%22">Gao R</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+S%22">Yoon S</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22McCoig+E%22">McCoig E</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Jalloul+HA%22">Jalloul HA</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Myczek+K%22">Myczek K</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Khalatyan+N%22">Khalatyan N</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hall+EA%22">Hall EA</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Turk+LS%22">Turk LS</searchLink>; Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA.<br /><searchLink fieldCode="AU" term="%22Sanz-Clemente+A%22">Sanz-Clemente A</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Comoletti+D%22">Comoletti D</searchLink>; Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA; Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, NJ 08901, USA; School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand.<br /><searchLink fieldCode="AU" term="%22Lichtenthaler+SF%22">Lichtenthaler SF</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Department of Neuroproteomics, School of Medicine, Klinikum rechts der Isar, and Institute for Advanced Study, Technical University of Munich, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Burgdorf+JS%22">Burgdorf JS</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Barbolina+MV%22">Barbolina MV</searchLink>; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.<br /><searchLink fieldCode="AU" term="%22Savas+JN%22">Savas JN</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Penzes+P%22">Penzes P</searchLink>; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Center for Autism and Neurodevelopment, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: p-penzes@northwestern.edu.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2022 Feb 16; Vol. 110 (4), pp. 627-643.e9. <i>Date of Electronic Publication: </i>2021 Dec 17.
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