Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome.
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| Title: | Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome. |
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| Authors: | Dutrow EV; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.; Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Emera D; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.; Center for Reproductive Longevity and Equality, Buck Institute for Research on Aging, Novato, CA, 94945, USA., Yim K; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Uebbing S; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Kocher AA; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Krenzer M; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.; Neuroscience Research Training Program, Department of Psychiatry, Yale School of Medicine, New Haven, CT, 06510, USA., Nottoli T; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, 06510, USA.; Yale Genome Editing Center, Yale School of Medicine, New Haven, CT, 06510, USA., Burkhardt DB; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.; Cellarity, Cambridge, MA, 02139, USA., Krishnaswamy S; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA.; Department of Computer Science, Yale University, New Haven, CT, 06520, USA., Louvi A; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA., Noonan JP; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA. james.noonan@yale.edu.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, 06510, USA. james.noonan@yale.edu.; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, 06520, USA. james.noonan@yale.edu. |
| Source: | Nature communications [Nat Commun] 2022 Jan 13; Vol. 13 (1), pp. 304. Date of Electronic Publication: 2022 Jan 13. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-27899-w |
