Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
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| Title: | Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. |
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| Authors: | Tan YB; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921., Lello LS; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia., Liu X; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China., Law YS; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921., Kang C; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), 10 Biopolis Rd, #05-01/06 Chromos, Singapore138670., Lescar J; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore., Zheng J; Shanghai Institute of Materia Medica, China Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China., Merits A; University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia., Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; NTU Institute of Structural Biology, Nanyang Technological University, 59 Nanyang Drive, Singapore 636921.; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2022 Jan 25; Vol. 50 (2), pp. 1000-1016. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkab1302 |
