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Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers.

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Bibliographic Details
Title: Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers.
Authors: Smith CR; Mirati Therapeutics, San Diego, California 92121, United States., Aranda R; Mirati Therapeutics, San Diego, California 92121, United States., Bobinski TP; DSG, San Diego, California 92130, United States., Briere DM; Mirati Therapeutics, San Diego, California 92121, United States., Burns AC; Mirati Therapeutics, San Diego, California 92121, United States., Christensen JG; Mirati Therapeutics, San Diego, California 92121, United States., Clarine J; Mirati Therapeutics, San Diego, California 92121, United States., Engstrom LD; Mirati Therapeutics, San Diego, California 92121, United States., Gunn RJ; Mirati Therapeutics, San Diego, California 92121, United States., Ivetac A; Mirati Therapeutics, San Diego, California 92121, United States., Jean-Baptiste R; ZoBio BV, J. H. Oortweg 19, 2333 CH Leiden, Netherlands., Ketcham JM; Mirati Therapeutics, San Diego, California 92121, United States., Kobayashi M; ZoBio BV, J. H. Oortweg 19, 2333 CH Leiden, Netherlands., Kuehler J; Mirati Therapeutics, San Diego, California 92121, United States., Kulyk S; Mirati Therapeutics, San Diego, California 92121, United States., Lawson JD; Mirati Therapeutics, San Diego, California 92121, United States., Moya K; Mirati Therapeutics, San Diego, California 92121, United States., Olson P; Mirati Therapeutics, San Diego, California 92121, United States., Rahbaek L; Mirati Therapeutics, San Diego, California 92121, United States., Thomas NC; Mirati Therapeutics, San Diego, California 92121, United States., Wang X; Mirati Therapeutics, San Diego, California 92121, United States., Waters LM; Mirati Therapeutics, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Feb 10; Vol. 65 (3), pp. 1749-1766. Date of Electronic Publication: 2022 Jan 18.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.1c01900