Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells.

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Title: Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells.
Authors: van Lith SAM; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Huizing FJ; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Franssen GM; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Hoeben BAW; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands., Lok J; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Doulkeridou S; Department of Cell Biology, University of Utrecht, Utrecht, 3584 GE, The Netherlands., Boerman OC; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Gotthardt M; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., van Bergen En Henegouwen PMP; Department of Cell Biology, University of Utrecht, Utrecht, 3584 GE, The Netherlands., Bussink J; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands., Heskamp S; Department of Medical Imaging, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Source: Molecular pharmaceutics [Mol Pharm] 2022 Oct 03; Vol. 19 (10), pp. 3511-3520. Date of Electronic Publication: 2022 Jan 19.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1543-8392
DOI:10.1021/acs.molpharmaceut.1c00841