Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.

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Title: Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences.
Authors: Lee JY; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Wing PAC; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom., Gala DS; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Noerenberg M; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., Järvelin AI; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Titlow J; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Zhuang X; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom., Palmalux N; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., Iselin L; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Thompson MK; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Parton RM; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom., Prange-Barczynska M; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom., Wainman A; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom., Salguero FJ; UK Health Security Agency, UKHSA-Porton Down, Salisbury, United Kingdom., Bishop T; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Ludwig Institute for Cancer Research, The University of Oxford, Oxford, United Kingdom., Agranoff D; Department of Infectious Diseases, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom., James W; Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom.; James & Lillian Martin Centre, Sir William Dunn School of Pathology, The University of Oxford, Oxford, United Kingdom., Castello A; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.; MRC-University of Glasgow Centre for Virus Research, The University of Glasgow, Glasgow, United Kingdom., McKeating JA; Nuffield Department of Medicine, The University of Oxford, Oxford, United Kingdom.; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), The University of Oxford, Oxford, United Kingdom., Davis I; Department of Biochemistry, The University of Oxford, Oxford, United Kingdom.
Source: ELife [Elife] 2022 Jan 20; Vol. 11. Date of Electronic Publication: 2022 Jan 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2050-084X
DOI:10.7554/eLife.74153