In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells.

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Title: In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells.
Authors: Huang B; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. bonniehuangnih@gmail.com.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA. bonniehuangnih@gmail.com., Phelan JD; National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Preite S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Gomez-Rodriguez J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.; TCR2 Therapeutics, Cambridge, MA, 02142, USA., Johansen KH; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Shibata H; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Shaffer AL 3rd; National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Xu Q; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Jeffrey B; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Kirby M; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Anderson S; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Yang Y; National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Gossa S; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA., McGavern DB; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA., Staudt LM; National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Schwartzberg PL; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. pams@nih.gov.; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA. pams@nih.gov.
Source: Nature communications [Nat Commun] 2022 Feb 10; Vol. 13 (1), pp. 805. Date of Electronic Publication: 2022 Feb 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-022-28378-6