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Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.

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Title: Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.
Authors: Achison M; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Adamson S; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Akpan A; Clinical Research Network Northwest Coast, University of Liverpool, Liverpool University Hospitals NHS FT Trust, Liverpool, UK., Aspray T; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University and Newcastle-upon-Tyne NHS Trust, Newcastle upon Tyne, UK., Avenell A; Health Services Research Unit, University of Aberdeen, Aberdeen, UK., Band MM; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Bashir T; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK., Burton LA; Medicine for the Elderly, NHS Tayside, Dundee, UK and Ageing and Health, University of Dundee, Dundee, UK., Cvoro V; Victoria Hospital, Kirkcaldy, UK.; Centre for Clinical Brain Sciences University of Edinburgh, Edinburgh, UK., Donnan PT; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Duncan GW; Medicine for the Elderly, NHS Lothian, Edinburgh, UK and Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., George J; Department of Clinical Pharmacology, Division of Molecular & Clinical Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, UK., Gordon AL; Unit of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.; Department of Medicine for the Elderly, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK., Gregson CL; Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, UK.; Older Person's Unit, Royal United Hospital NHS Foundation Trust Bath, Bath, UK., Hapca A; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Henderson E; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Royal United Hospital Bath NHS Foundation Trust, Bath, UK., Hume C; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Jackson TA; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Kemp P; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK., Kerr S; Department of Older People's Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Kilgour A; Medicine for the Elderly, NHS Lothian, Edinburgh, UK., Lyell V; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Masud T; Clinical Gerontology Research Unit, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK., McKenzie A; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., McKenzie E; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Patel H; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHSFT, Southampton, UK., Pilvinyte K; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Roberts HC; Academic Geriatric Medicine, University of Southampton, Mailpoint 807 Southampton General Hospital, Southampton, UK., Rossios C; Cardiovascular and Respiratory Interface Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK., Sayer AA; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University and Newcastle-upon-Tyne NHS Trust, Newcastle upon Tyne, UK., Smith KT; Tayside Clinical Trials Unit (TCTU), Tayside Medical Science Centre (TASC), University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Soiza RL; Ageing & Clinical Experimental Research (ACER) Group, University of Aberdeen, Aberdeen, UK., Steves CJ; Department of Twin Research and Genetic Epidemiology, King's College London & Department of Clinical Gerontology, King's College Hospital, London, UK., Struthers AD; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital, Dundee, UK., Sumukadas D; Department of Medicine for the Elderly, NHS Tayside, Dundee, UK., Tiwari D; Bournemouth University and Royal Bournemouth Hospital, Bournemouth, UK., Whitney J; School of Population Health & Environmental Sciences, King's College London and King's College Hospital, London, UK., Witham MD; AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational Clinical Research Institute, Newcastle University and Newcastle-upon-Tyne NHS Trust, Newcastle upon Tyne, UK.
Corporate Authors: LACE study group
Source: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2022 Apr; Vol. 13 (2), pp. 858-871. Date of Electronic Publication: 2022 Feb 16.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2190-6009
DOI:10.1002/jcsm.12934