Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
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| Title: | Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting. |
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| Authors: | Jouandin P; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Marelja Z; Université de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France.; Institute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany., Shih YH; Institute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany., Parkhitko AA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Dambowsky M; Université de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France., Asara JM; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02175, USA., Nemazanyy I; Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633, Paris 75015, France., Dibble CC; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA., Simons M; Université de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France.; Institute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany., Perrimon N; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. |
| Source: | Science (New York, N.Y.) [Science] 2022 Feb 18; Vol. 375 (6582), pp. eabc4203. Date of Electronic Publication: 2022 Feb 18. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abc4203 |
