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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.

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Title: Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
Authors: Muik A; BioNTech, Mainz, Germany., Garralda E; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., Altintas I; Genmab B.V., Utrecht, the Netherlands., Gieseke F; BioNTech, Mainz, Germany., Geva R; Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ben-Ami E; Department of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel., Maurice-Dror C; Institute of Oncology, Rambam Health Care Campus, Haifa, Israel., Calvo E; START Madrid-CIOCC, Clara Campal Comprehensive Cancer Center, Madrid, Spain., LoRusso PM; Yale Cancer Center, Yale University, New Haven, Connecticut., Alonso G; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain., Rodriguez-Ruiz ME; Radiation Oncology Department, Clínica Universidad de Navarra, Pamplona, Spain., Schoedel KB; BioNTech, Mainz, Germany., Blum JM; Genmab U.S. Inc., Princeton, New Jersey., Sänger B; BioNTech, Mainz, Germany., Salcedo TW; Genmab U.S. Inc., Princeton, New Jersey., Burm SM; Genmab B.V., Utrecht, the Netherlands., Stanganello E; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Verzijl D; Genmab B.V., Utrecht, the Netherlands., Vascotto F; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Sette A; Genmab B.V., Utrecht, the Netherlands., Quinkhardt J; BioNTech, Mainz, Germany., Plantinga TS; Genmab B.V., Utrecht, the Netherlands., Toker A; BioNTech, Mainz, Germany., van den Brink EN; Genmab B.V., Utrecht, the Netherlands., Fereshteh M; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Diken M; BioNTech, Mainz, Germany., Satijn D; Genmab B.V., Utrecht, the Netherlands., Kreiter S; BioNTech, Mainz, Germany., Breij ECW; Genmab B.V., Utrecht, the Netherlands., Bajaj G; Genmab U.S. Inc., Princeton, New Jersey., Lagkadinou E; BioNTech, Mainz, Germany., Sasser K; Genmab U.S. Inc., Princeton, New Jersey., Türeci Ö; BioNTech, Mainz, Germany., Forssmann U; Genmab A/S, Copenhagen, Denmark., Ahmadi T; Genmab U.S. Inc., Princeton, New Jersey., Şahin U; BioNTech, Mainz, Germany., Jure-Kunkel M; Genmab U.S. Inc., Princeton, New Jersey., Melero I; Department of Immunology, Clínica Universidad de Navarra and CIBERONC, Pamplona, Spain.
Source: Cancer discovery [Cancer Discov] 2022 May 02; Vol. 12 (5), pp. 1248-1265.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
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START Madrid-CIOCC, Clara Campal Comprehensive Cancer Center, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22LoRusso+PM%22">LoRusso PM</searchLink>; Yale Cancer Center, Yale University, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Alonso+G%22">Alonso G</searchLink>; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Ruiz+ME%22">Rodriguez-Ruiz ME</searchLink>; Radiation Oncology Department, Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Schoedel+KB%22">Schoedel KB</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Blum+JM%22">Blum JM</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Sänger+B%22">Sänger B</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Salcedo+TW%22">Salcedo TW</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Burm+SM%22">Burm SM</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Stanganello+E%22">Stanganello E</searchLink>; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Verzijl+D%22">Verzijl D</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vascotto+F%22">Vascotto F</searchLink>; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Quinkhardt+J%22">Quinkhardt J</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Plantinga+TS%22">Plantinga TS</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Toker+A%22">Toker A</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+EN%22">van den Brink EN</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fereshteh+M%22">Fereshteh M</searchLink>; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Diken+M%22">Diken M</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Satijn+D%22">Satijn D</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kreiter+S%22">Kreiter S</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Breij+ECW%22">Breij ECW</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bajaj+G%22">Bajaj G</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Lagkadinou+E%22">Lagkadinou E</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Sasser+K%22">Sasser K</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Türeci+Ö%22">Türeci Ö</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Forssmann+U%22">Forssmann U</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ahmadi+T%22">Ahmadi T</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Şahin+U%22">Şahin U</searchLink>; BioNTech, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab U.S. Inc., Princeton, New Jersey.<br /><searchLink fieldCode="AU" term="%22Melero+I%22">Melero I</searchLink>; Department of Immunology, Clínica Universidad de Navarra and CIBERONC, Pamplona, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2022 May 02; Vol. 12 (5), pp. 1248-1265.
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