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RP-HPLC separation of interconvertible rotamers of a 5-tetrahydroisoquinolin-6-yl-pyridin-3-yl acetic acid derivative and confirmation by VT NMR and DFT study.

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Title: RP-HPLC separation of interconvertible rotamers of a 5-tetrahydroisoquinolin-6-yl-pyridin-3-yl acetic acid derivative and confirmation by VT NMR and DFT study.
Authors: Chauthe SK; Discovery Analytical Sciences, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Sidduri P; Discovery Analytical Sciences, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Reddy M; Discovery Analytical Sciences, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Sistla R; Department of Medicinal Chemistry, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Byri V; Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Uttaravalli MD; Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Botlagunta M; Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Kumar H; Discovery Analytical Sciences, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Gupta A; Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Gupta AK; Department of Discovery Synthesis, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Bajpai L; Department of Analytical Research & Development, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India., Bagadi M; Discovery Analytical Sciences, Biocon Bristol Myers Squibb Research & Development Center (BBRC), Bangalore, India. Electronic address: muralidhararao.b@syngeneintl.com., Mathur A; Small Molecule Drug Discovery, Bristol Myers Squibb Research and Development, P.O. Box 5400, Princeton, NJ 08543-4000, USA.
Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2022 Apr 01; Vol. 212, pp. 114675. Date of Electronic Publication: 2022 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-264X
DOI:10.1016/j.jpba.2022.114675