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Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.

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Title: Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
Authors: Ibrahim AIM; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan., Batlle E; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Sneha S; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K., Jiménez R; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Pequerul R; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Parés X; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Rüngeler T; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Jha V; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Tuccinardi T; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Sadiq M; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K., Frame F; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K., Maitland NJ; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K., Farrés J; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain., Pors K; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 3833-3848. Date of Electronic Publication: 2022 Feb 25.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ibrahim+AIM%22">Ibrahim AIM</searchLink>; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.<br /><searchLink fieldCode="AU" term="%22Batlle+E%22">Batlle E</searchLink>; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Sneha+S%22">Sneha S</searchLink>; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.<br /><searchLink fieldCode="AU" term="%22Jiménez+R%22">Jiménez R</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Pequerul+R%22">Pequerul R</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Parés+X%22">Parés X</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Rüngeler+T%22">Rüngeler T</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Jha+V%22">Jha V</searchLink>; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Tuccinardi+T%22">Tuccinardi T</searchLink>; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Sadiq+M%22">Sadiq M</searchLink>; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K.<br /><searchLink fieldCode="AU" term="%22Frame+F%22">Frame F</searchLink>; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K.<br /><searchLink fieldCode="AU" term="%22Maitland+NJ%22">Maitland NJ</searchLink>; Cancer Research Unit, Department of Biology, University of York, Heslington, Yorkshire YO10 5DD, U.K.<br /><searchLink fieldCode="AU" term="%22Farrés+J%22">Farrés J</searchLink>; Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona E-08193, Spain.<br /><searchLink fieldCode="AU" term="%22Pors+K%22">Pors K</searchLink>; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Yorkshire BD7 1DP, U.K.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 3833-3848. <i>Date of Electronic Publication: </i>2022 Feb 25.
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