A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
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| Title: | A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M |
|---|---|
| Authors: | Nathan PJ; Heptares Therapeutics Ltd Cambridge UK.; Department of Psychiatry University of Cambridge Cambridge UK., Millais SB; Heptares Therapeutics Ltd Cambridge UK., Godwood A; Heptares Therapeutics Ltd Cambridge UK., Dewit O; Heptares Therapeutics Ltd Cambridge UK., Cross DM; Cross Pharma Consulting Limited Cambridge UK., Liptrot J; Heptares Therapeutics Ltd Cambridge UK., Ruparelia B; Heptares Therapeutics Ltd Cambridge UK., Jones SP; tranScrip Partners LLP Wokingham UK., Bakker G; Heptares Therapeutics Ltd Cambridge UK., Maruff PT; Cogstate Ltd New Haven Connecticut USA., Light GA; Department of Psychiatry University of San Diego San Diego California USA., Brown AJH; Heptares Therapeutics Ltd Cambridge UK., Weir MP; Heptares Therapeutics Ltd Cambridge UK., Congreve M; Heptares Therapeutics Ltd Cambridge UK., Tasker T; Heptares Therapeutics Ltd Cambridge UK. |
| Source: | Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Feb 23; Vol. 8 (1), pp. e12273. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley on behalf of the Alzheimer's Association Country of Publication: United States NLM ID: 101650118 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-8737 (Electronic) Linking ISSN: 23528737 NLM ISO Abbreviation: Alzheimers Dement (N Y) Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 35229025 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M<subscript>1</subscript> receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nathan+PJ%22">Nathan PJ</searchLink>; Heptares Therapeutics Ltd Cambridge UK.; Department of Psychiatry University of Cambridge Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Millais+SB%22">Millais SB</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Godwood+A%22">Godwood A</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Dewit+O%22">Dewit O</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Cross+DM%22">Cross DM</searchLink>; Cross Pharma Consulting Limited Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Liptrot+J%22">Liptrot J</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Ruparelia+B%22">Ruparelia B</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Jones+SP%22">Jones SP</searchLink>; tranScrip Partners LLP Wokingham UK.<br /><searchLink fieldCode="AU" term="%22Bakker+G%22">Bakker G</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Maruff+PT%22">Maruff PT</searchLink>; Cogstate Ltd New Haven Connecticut USA.<br /><searchLink fieldCode="AU" term="%22Light+GA%22">Light GA</searchLink>; Department of Psychiatry University of San Diego San Diego California USA.<br /><searchLink fieldCode="AU" term="%22Brown+AJH%22">Brown AJH</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Weir+MP%22">Weir MP</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Congreve+M%22">Congreve M</searchLink>; Heptares Therapeutics Ltd Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Tasker+T%22">Tasker T</searchLink>; Heptares Therapeutics Ltd Cambridge UK. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101650118%22">Alzheimer's & dementia (New York, N. Y.)</searchLink> [Alzheimers Dement (N Y)] 2022 Feb 23; Vol. 8 (1), pp. e12273. <i>Date of Electronic Publication: </i>2022 Feb 23 (<i>Print Publication: </i>2022). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+on+behalf+of+the+Alzheimer's+Association%22">Wiley on behalf of the Alzheimer's Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101650118 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-8737 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223528737%22">23528737 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement (N Y) <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35229025 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/trc2.12273 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e12273 Titles: – TitleFull: A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nathan PJ – PersonEntity: Name: NameFull: Millais SB – PersonEntity: Name: NameFull: Godwood A – PersonEntity: Name: NameFull: Dewit O – PersonEntity: Name: NameFull: Cross DM – PersonEntity: Name: NameFull: Liptrot J – PersonEntity: Name: NameFull: Ruparelia B – PersonEntity: Name: NameFull: Jones SP – PersonEntity: Name: NameFull: Bakker G – PersonEntity: Name: NameFull: Maruff PT – PersonEntity: Name: NameFull: Light GA – PersonEntity: Name: NameFull: Brown AJH – PersonEntity: Name: NameFull: Weir MP – PersonEntity: Name: NameFull: Congreve M – PersonEntity: Name: NameFull: Tasker T IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 02 Text: 2022 Feb 23 Type: published Y: 2022 Identifiers: – Type: issn-electronic Value: 2352-8737 Numbering: – Type: volume Value: 8 – Type: issue Value: 1 Titles: – TitleFull: Alzheimer's & dementia (New York, N. Y.) Type: main |
| ResultId | 1 |
