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Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.

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Title: Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.
Authors: Chung H; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Merakou C; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA., Schaefers MM; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA., Flett KB; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Novant Health Eastover Pediatrics, Charlotte, NC, USA., Martini S; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA., Lu R; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA., Blumenthal JA; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA., Webster SS; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Cross AR; Division of Pulmonary, Allergy & Immunology, Cystic Fibrosis and Sleep, Emory Children's Center for Cystic Fibrosis and Airway Disease Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., Al Ahmar R; Department of Biomedical Science, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA., Halpin E; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Winchester Hospital, Winchester, MA, USA., Anderson M; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Becton Dickinson, Franklin Lakes, NJ, USA., Moore NS; Harvard Medical School, Boston, MA, USA., Snesrud EC; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Yu HD; Department of Biomedical Science, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.; Department of Pediatrics, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA., Goldberg JB; Division of Pulmonary, Allergy & Immunology, Cystic Fibrosis and Sleep, Emory Children's Center for Cystic Fibrosis and Airway Disease Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA., O'Toole GA; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., McGann P; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Stam JA; Walter Reed Army Institute of Research, Silver Spring, MD, USA., Hinkle M; Walter Reed Army Institute of Research, Silver Spring, MD, USA., McAdam AJ; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA., Kishony R; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. rkishony@technion.ac.il.; Faculty of Biology and Computer Science, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il., Priebe GP; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. gregory.priebe@childrens.harvard.edu.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA. gregory.priebe@childrens.harvard.edu.
Source: Nature communications [Nat Commun] 2022 Mar 09; Vol. 13 (1), pp. 1231. Date of Electronic Publication: 2022 Mar 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chung+H%22">Chung H</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Merakou+C%22">Merakou C</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schaefers+MM%22">Schaefers MM</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flett+KB%22">Flett KB</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Novant Health Eastover Pediatrics, Charlotte, NC, USA.<br /><searchLink fieldCode="AU" term="%22Martini+S%22">Martini S</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+R%22">Lu R</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Blumenthal+JA%22">Blumenthal JA</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Webster+SS%22">Webster SS</searchLink>; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22Cross+AR%22">Cross AR</searchLink>; Division of Pulmonary, Allergy & Immunology, Cystic Fibrosis and Sleep, Emory Children's Center for Cystic Fibrosis and Airway Disease Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Al+Ahmar+R%22">Al Ahmar R</searchLink>; Department of Biomedical Science, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.<br /><searchLink fieldCode="AU" term="%22Halpin+E%22">Halpin E</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Winchester Hospital, Winchester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+M%22">Anderson M</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.; Becton Dickinson, Franklin Lakes, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Moore+NS%22">Moore NS</searchLink>; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Snesrud+EC%22">Snesrud EC</searchLink>; Walter Reed Army Institute of Research, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yu+HD%22">Yu HD</searchLink>; Department of Biomedical Science, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.; Department of Pediatrics, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+JB%22">Goldberg JB</searchLink>; Division of Pulmonary, Allergy & Immunology, Cystic Fibrosis and Sleep, Emory Children's Center for Cystic Fibrosis and Airway Disease Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22O'Toole+GA%22">O'Toole GA</searchLink>; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.<br /><searchLink fieldCode="AU" term="%22McGann+P%22">McGann P</searchLink>; Walter Reed Army Institute of Research, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Stam+JA%22">Stam JA</searchLink>; Walter Reed Army Institute of Research, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hinkle+M%22">Hinkle M</searchLink>; Walter Reed Army Institute of Research, Silver Spring, MD, USA.<br /><searchLink fieldCode="AU" term="%22McAdam+AJ%22">McAdam AJ</searchLink>; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kishony+R%22">Kishony R</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. rkishony@technion.ac.il.; Faculty of Biology and Computer Science, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il.<br /><searchLink fieldCode="AU" term="%22Priebe+GP%22">Priebe GP</searchLink>; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, USA. gregory.priebe@childrens.harvard.edu.; Department of Anaesthesia, Harvard Medical School, Boston, MA, USA. gregory.priebe@childrens.harvard.edu.
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