Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes.
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| Title: | Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. |
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| Authors: | Seyres D; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK. ds777@medschl.cam.ac.uk.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. ds777@medschl.cam.ac.uk.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK. ds777@medschl.cam.ac.uk., Cabassi A; MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Lambourne JJ; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Burden F; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Farrow S; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., McKinney H; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Batista J; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Kempster C; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Pietzner M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Slingsby O; Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Cao TH; Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Quinn PA; Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Stefanucci L; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.; British Heart Foundation Centre of Excellence, Cambridge Biomedical Campus, Cambridge, UK., Sims MC; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.; Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, NIHR Oxford Biomedical Research Centre, Oxford, UK., Rehnstrom K; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Adams CL; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Frary A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Ergüener B; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kreuzhuber R; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Mocciaro G; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, The Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., D'Amore S; Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Medicine, Aldo Moro University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy.; National Cancer Research Center, IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco, 65, 70124, Bari, Italy., Koulman A; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; MRC Elsie Widdowson Laboratory, Cambridge, UK.; National Institute for Health Research Biomedical Research Centres Core Nutritional Biomarker Laboratory, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; National Institute for Health Research Biomedical Research Centres Core Metabolomics and Lipidomics Laboratory, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Grassi L; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK., Griffin JL; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, The Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Ng LL; Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Park A; Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Savage DB; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Downes K; National Institute for Health Research BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; East Midlands and East of England Genomic Laboratory Hub, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Allison M; Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Vacca M; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, The Sanger Building, 80 Tennis Court Road, Cambridge, CB2 1GA, UK., Kirk PDW; MRC Biostatistics Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. paul.kirk@mrc-bsu.cam.ac.uk.; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge Biomedical Campus, Puddicombe Way, Cambridge, CB2 0AW, UK. paul.kirk@mrc-bsu.cam.ac.uk., Frontini M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. mf471@cam.ac.uk.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK. mf471@cam.ac.uk.; British Heart Foundation Centre of Excellence, Cambridge Biomedical Campus, Cambridge, UK. mf471@cam.ac.uk.; Institute of Biomedical & Clinical Science, College of Medicine and Health, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK. mf471@cam.ac.uk. |
| Source: | Clinical epigenetics [Clin Epigenetics] 2022 Mar 12; Vol. 14 (1), pp. 39. Date of Electronic Publication: 2022 Mar 12. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Biomed Central Country of Publication: Germany NLM ID: 101516977 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-7083 (Electronic) Linking ISSN: 18687075 NLM ISO Abbreviation: Clin Epigenetics Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1868-7083 |
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| DOI: | 10.1186/s13148-022-01257-z |
