Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2.

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Title: Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2.
Authors: Wu S; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, China., Lin C; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China., Zhang T; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, China., Zhang B; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, China., Jin Y; Department of Immunology and Department of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada., Wang H; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China., Li H; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China., Wang Y; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China., Wang X; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, China.; Beijing National Laboratory for Molecular Sciences, Beijing, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2022 Feb 23; Vol. 13, pp. 835081. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1663-9812
DOI:10.3389/fphar.2022.835081