The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
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| Title: | The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL. |
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| Authors: | Jacobsen AV; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Pierotti CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Lowes KN; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Au AE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Zhang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Etemadi N; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Fitzgibbon C; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Kersten WJA; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Samson AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., van Delft MF; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Huang DCS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Sabroux HJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Lessene G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. silke@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. silke@wehi.edu.au., Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au. |
| Source: | Cell death & disease [Cell Death Dis] 2022 Apr 01; Vol. 13 (4), pp. 291. Date of Electronic Publication: 2022 Apr 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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