Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.

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Title: Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir.
Authors: Singh RSP; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Toussi SS; Pfizer Worldwide Research, Development and Medical, Pearl River, New York, USA., Hackman F; Pfizer Worldwide Research, Development and Medical, Cambridge, UK., Chan PL; Pfizer Global Product Development, Sandwich, UK., Rao R; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Allen R; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Van Eyck L; Pfizer Clinical Research Unit, Brussels, Belgium., Pawlak S; Pfizer Clinical Research Unit, New Haven, Connecticut, USA., Kadar EP; Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA., Clark F; Pfizer Worldwide Research, Development and Medical, Groton, Connecticut, USA., Shi H; Pfizer Global Product Development, Groton, Connecticut, USA., Anderson AS; Pfizer Worldwide Research, Development and Medical, Pearl River, New York, USA., Binks M; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Menon S; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Nucci G; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA., Bergman A; Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, USA.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Jul; Vol. 112 (1), pp. 101-111. Date of Electronic Publication: 2022 May 04.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1532-6535
DOI:10.1002/cpt.2603