Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.

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Title: Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
Authors: Zhang R; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Chen D; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA., Fan H; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Wu R; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Tu J; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Zhang FQ; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Wang M; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA., Zheng H; Department of Pediatrics and Aflac Cancer and Blood Disorder Center, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA., Qu CK; Department of Pediatrics and Aflac Cancer and Blood Disorder Center, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA., Elf SE; The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA., Faubert B; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., He YY; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Bissonnette MB; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA., Gao X; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: xgao30@uchicago.edu., DeBerardinis RJ; UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: ralph.deberardinis@utsouthwestern.edu., Chen J; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: jingchen@medicine.bsd.uchicago.edu.
Source: Cell chemical biology [Cell Chem Biol] 2022 Jul 21; Vol. 29 (7), pp. 1200-1208.e6. Date of Electronic Publication: 2022 Apr 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2451-9448
DOI:10.1016/j.chembiol.2022.03.010