Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
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| Title: | Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. |
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| Authors: | Riemenschneider H; German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany., Guo Q; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.; State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China., Bader J; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany., Frottin F; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Martinsried, Germany.; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France., Farny D; German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany., Kleinberger G; German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany.; Chair of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität Munich, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany., Hartl FU; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Martinsried, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany., Baumeister W; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Hipp MS; Department of Cellular Biochemistry, Max Planck Institute for Biochemistry, Martinsried, Germany.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany., Meissner F; Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany.; Department of Systems Immunology and Proteomics, Medical Faculty, Institute of Innate Immunity, University of Bonn, Germany., Fernández-Busnadiego R; Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, Martinsried, Germany.; Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), Munich, Munich, Germany.; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians-University Munich, Munich, Germany. |
| Source: | EMBO reports [EMBO Rep] 2022 Jun 07; Vol. 23 (6), pp. e53890. Date of Electronic Publication: 2022 Apr 19. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1469-3178 |
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| DOI: | 10.15252/embr.202153890 |
