Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.

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Bibliographic Details
Title: Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Authors: Corry SM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCorry AM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Lannagan TR; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Leonard NA; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland., Fisher NC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Byrne RM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tsantoulis P; Université de Genève, Geneva, Switzerland., Cortes-Lavaud X; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Amirkhah R; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Redmond KL; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCooey AJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Malla SB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Rogan E; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Sakhnevych S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Gillespie MA; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., White M; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Richman SD; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Jackstadt RF; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) and Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Campbell AD; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Maguire S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McDade SS; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Longley DB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Loughrey MB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK.; Centre for Public Health, Queens University Belfast, Belfast, UK., Coleman HG; Centre for Public Health, Queens University Belfast, Belfast, UK., Kerr EM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tejpar S; Digestive Oncology Unit, University Ospital Gasthuisberg, Leuven, Belgium., Maughan T; Department of Oncology, University of Oxford, Oxford, UK., Leedham SJ; Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Small DM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Ryan AE; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland., Sansom OJ; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Lawler M; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Dunne PD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK p.dunne@qub.ac.uk.
Corporate Authors: S:CORT and ACRCelerate consortia
Source: Gut [Gut] 2022 Dec; Vol. 71 (12), pp. 2502-2517. Date of Electronic Publication: 2022 Apr 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-3288
DOI:10.1136/gutjnl-2021-326183