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Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.

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Title: Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Authors: Corry SM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCorry AM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Lannagan TR; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Leonard NA; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland., Fisher NC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Byrne RM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tsantoulis P; Université de Genève, Geneva, Switzerland., Cortes-Lavaud X; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Amirkhah R; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Redmond KL; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCooey AJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Malla SB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Rogan E; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Sakhnevych S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Gillespie MA; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., White M; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Richman SD; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Jackstadt RF; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) and Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ), Heidelberg, Germany., Campbell AD; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK., Maguire S; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McDade SS; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Longley DB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Loughrey MB; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK.; Centre for Public Health, Queens University Belfast, Belfast, UK., Coleman HG; Centre for Public Health, Queens University Belfast, Belfast, UK., Kerr EM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Tejpar S; Digestive Oncology Unit, University Ospital Gasthuisberg, Leuven, Belgium., Maughan T; Department of Oncology, University of Oxford, Oxford, UK., Leedham SJ; Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Small DM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Ryan AE; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland., Sansom OJ; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Lawler M; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Dunne PD; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK p.dunne@qub.ac.uk.
Corporate Authors: S:CORT and ACRCelerate consortia
Source: Gut [Gut] 2022 Dec; Vol. 71 (12), pp. 2502-2517. Date of Electronic Publication: 2022 Apr 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
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  Data: Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
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  Data: <searchLink fieldCode="AU" term="%22Corry+SM%22">Corry SM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McCorry+AM%22">McCorry AM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Lannagan+TR%22">Lannagan TR</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Leonard+NA%22">Leonard NA</searchLink>; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Fisher+NC%22">Fisher NC</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Byrne+RM%22">Byrne RM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Tsantoulis+P%22">Tsantoulis P</searchLink>; Université de Genève, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cortes-Lavaud+X%22">Cortes-Lavaud X</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Amirkhah+R%22">Amirkhah R</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Redmond+KL%22">Redmond KL</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McCooey+AJ%22">McCooey AJ</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Malla+SB%22">Malla SB</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Rogan+E%22">Rogan E</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Sakhnevych+S%22">Sakhnevych S</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Gillespie+MA%22">Gillespie MA</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22White+M%22">White M</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Richman+SD%22">Richman SD</searchLink>; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Jackstadt+RF%22">Jackstadt RF</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) and Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Campbell+AD%22">Campbell AD</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Maguire+S%22">Maguire S</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McDade+SS%22">McDade SS</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Longley+DB%22">Longley DB</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Loughrey+MB%22">Loughrey MB</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK.; Centre for Public Health, Queens University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Coleman+HG%22">Coleman HG</searchLink>; Centre for Public Health, Queens University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Kerr+EM%22">Kerr EM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Tejpar+S%22">Tejpar S</searchLink>; Digestive Oncology Unit, University Ospital Gasthuisberg, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maughan+T%22">Maughan T</searchLink>; Department of Oncology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Leedham+SJ%22">Leedham SJ</searchLink>; Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Small+DM%22">Small DM</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Ryan+AE%22">Ryan AE</searchLink>; Lambe Institute for Translational Research, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland.; Discipline of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Sansom+OJ%22">Sansom OJ</searchLink>; Cancer Research UK, Beatson Institute for Cancer Research, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lawler+M%22">Lawler M</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Dunne+PD%22">Dunne PD</searchLink>; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK p.dunne@qub.ac.uk.
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        Value: 10.1136/gutjnl-2021-326183
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