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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.

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Title: Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Authors: Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA., Lee HW; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Gribble J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., George AS; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hughes TM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lu X; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Li J; Gilead Sciences Inc., Foster City, CA 94404, USA., Perry JK; Gilead Sciences Inc., Foster City, CA 94404, USA., Porter DP; Gilead Sciences Inc., Foster City, CA 94404, USA., Cihlar T; Gilead Sciences Inc., Foster City, CA 94404, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Götte M; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Aug 03; Vol. 14 (656), pp. eabo0718. Date of Electronic Publication: 2022 Aug 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Stevens+LJ%22">Stevens LJ</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Pruijssers+AJ%22">Pruijssers AJ</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Lee+HW%22">Lee HW</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.<br /><searchLink fieldCode="AU" term="%22Gordon+CJ%22">Gordon CJ</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.<br /><searchLink fieldCode="AU" term="%22Tchesnokov+EP%22">Tchesnokov EP</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.<br /><searchLink fieldCode="AU" term="%22Gribble+J%22">Gribble J</searchLink>; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22George+AS%22">George AS</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+TM%22">Hughes TM</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Gilead Sciences Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Perry+JK%22">Perry JK</searchLink>; Gilead Sciences Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Porter+DP%22">Porter DP</searchLink>; Gilead Sciences Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Cihlar+T%22">Cihlar T</searchLink>; Gilead Sciences Inc., Foster City, CA 94404, USA.<br /><searchLink fieldCode="AU" term="%22Sheahan+TP%22">Sheahan TP</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Baric+RS%22">Baric RS</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Götte+M%22">Götte M</searchLink>; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada.<br /><searchLink fieldCode="AU" term="%22Denison+MR%22">Denison MR</searchLink>; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2022 Aug 03; Vol. 14 (656), pp. eabo0718. <i>Date of Electronic Publication: </i>2022 Aug 03.
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