DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
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| Title: | DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. |
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| Authors: | Wielscher M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. matthias.wielscher@meduniwien.ac.at.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. matthias.wielscher@meduniwien.ac.at., Mandaviya PR; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands., Kuehnel B; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Joehanes R; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Mustafa R; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Robinson O; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Zhang Y; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Bodinier B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Walton E; Department of Psychology, University of Bath, Bath, UK.; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Mishra PP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Schlosser P; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Wilson R; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Tsai PC; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Department of Biomedical Sciences, Chang Gung University, Taoyuan City, Taiwan., Palaniswamy S; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland., Marioni RE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Fiorito G; Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Cugliari G; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Karhunen V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, Mashhad University of Medical Sciences, Mashhad, Iran., Psaty BM; Cardiovacular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Loh M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore., Bis JC; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Lehne B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Chadeau-Hyam M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Cardona A; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Selvin E; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Smith AK; Departments of Gynecology and Obstetrics & Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA, USA., Miller AH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Torres MA; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gào X; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., van Meurs JBJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Graf-Schindler J; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Resesarch at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Peters A; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Weninger W; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Farlik M; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Zhang T; Deptarment of Biostatistics, School of Public Health, Shandong University, Jinan, China., Chen W; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Xia Y; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Nauck M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Doerr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Tanaka T; Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fisher K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Kasela S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Vineis P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands., van der Harst P; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Iacoviello L; Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy.; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese-Como, Italy., Sacerdote C; Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital and Centre for Cancer Prevention, Turin, Italy., Panico S; Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy., Krogh V; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Tumino R; Cancer Registry and Histopathology Department, 'Civic - MPP Arezzo' Hospital, ASP Ragusa, Ragusa, Italy., Tzala E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Matullo G; Department of Medical Sciences, University of Turin, Turin, Italy.; AOU Città della Salute e della Scienza di Torino, Torino, Italy., Hurme MA; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Raitakari OT; Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baccarelli AA; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA., Kähönen M; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Herzig KH; Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland.; Department of Gastroenterology and Metabolism, Institute of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland., Li S; Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA., Conneely KN; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Heijmans BT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Relton C; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Ong KK; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Houston, TX, USA., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial Biomedical Research Centre, Imperial College London, London, UK.; British Heart Foundation, BHF, Centre for Research Excellence, Imperial College London, London, UK., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany., Beekman M; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands., Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK., Dehghan A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Järvelin MR; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. m.jarvelin@imperial.ac.uk.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK. m.jarvelin@imperial.ac.uk. |
| Corporate Authors: | BIOS consortium |
| Source: | Nature communications [Nat Commun] 2022 May 03; Vol. 13 (1), pp. 2408. Date of Electronic Publication: 2022 May 03. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-29792-6 |
