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DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.

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Title: DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
Authors: Wielscher M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. matthias.wielscher@meduniwien.ac.at.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. matthias.wielscher@meduniwien.ac.at., Mandaviya PR; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands., Kuehnel B; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Joehanes R; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Mustafa R; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Robinson O; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Zhang Y; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., Bodinier B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Walton E; Department of Psychology, University of Bath, Bath, UK.; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Mishra PP; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Schlosser P; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Wilson R; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Tsai PC; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Department of Biomedical Sciences, Chang Gung University, Taoyuan City, Taiwan., Palaniswamy S; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland., Marioni RE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Fiorito G; Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Cugliari G; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Karhunen V; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, Mashhad University of Medical Sciences, Mashhad, Iran., Psaty BM; Cardiovacular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Loh M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore., Bis JC; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Lehne B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Chadeau-Hyam M; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Brody JA; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Cardona A; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Selvin E; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Smith AK; Departments of Gynecology and Obstetrics & Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA, USA., Miller AH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Torres MA; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gào X; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany., van Meurs JBJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Graf-Schindler J; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany., Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Resesarch at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Peters A; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Weninger W; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Farlik M; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Zhang T; Deptarment of Biostatistics, School of Public Health, Shandong University, Jinan, China., Chen W; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Xia Y; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Nauck M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Doerr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Lehtimäki T; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland., Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Tanaka T; Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fisher K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Waite LL; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Kasela S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Vineis P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands., van der Harst P; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Iacoviello L; Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy.; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese-Como, Italy., Sacerdote C; Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital and Centre for Cancer Prevention, Turin, Italy., Panico S; Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy., Krogh V; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Tumino R; Cancer Registry and Histopathology Department, 'Civic - MPP Arezzo' Hospital, ASP Ragusa, Ragusa, Italy., Tzala E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Matullo G; Department of Medical Sciences, University of Turin, Turin, Italy.; AOU Città della Salute e della Scienza di Torino, Torino, Italy., Hurme MA; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Raitakari OT; Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Colicino E; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baccarelli AA; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA., Kähönen M; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland., Herzig KH; Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland.; Department of Gastroenterology and Metabolism, Institute of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland., Li S; Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA., Conneely KN; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Heijmans BT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Relton C; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK., Ong KK; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Houston, TX, USA., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial Biomedical Research Centre, Imperial College London, London, UK.; British Heart Foundation, BHF, Centre for Research Excellence, Imperial College London, London, UK., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany., Beekman M; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands., Levy D; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Chambers JC; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK., Dehghan A; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK., Järvelin MR; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. m.jarvelin@imperial.ac.uk.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK. m.jarvelin@imperial.ac.uk.
Corporate Authors: BIOS consortium
Source: Nature communications [Nat Commun] 2022 May 03; Vol. 13 (1), pp. 2408. Date of Electronic Publication: 2022 May 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
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  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wielscher+M%22">Wielscher M</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. matthias.wielscher@meduniwien.ac.at.; Department of Dermatology, Medical University of Vienna, Vienna, Austria. matthias.wielscher@meduniwien.ac.at.<br /><searchLink fieldCode="AU" term="%22Mandaviya+PR%22">Mandaviya PR</searchLink>; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuehnel+B%22">Kuehnel B</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Joehanes+R%22">Joehanes R</searchLink>; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mustafa+R%22">Mustafa R</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+O%22">Robinson O</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bodinier+B%22">Bodinier B</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Walton+E%22">Walton E</searchLink>; Department of Psychology, University of Bath, Bath, UK.; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Mishra+PP%22">Mishra PP</searchLink>; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Schlosser+P%22">Schlosser P</searchLink>; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wilson+R%22">Wilson R</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Tsai+PC%22">Tsai PC</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Department of Biomedical Sciences, Chang Gung University, Taoyuan City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Palaniswamy+S%22">Palaniswamy S</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Marioni+RE%22">Marioni RE</searchLink>; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Fiorito+G%22">Fiorito G</searchLink>; Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cugliari+G%22">Cugliari G</searchLink>; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Karhunen+V%22">Karhunen V</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ghanbari+M%22">Ghanbari M</searchLink>; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, Mashhad University of Medical Sciences, Mashhad, Iran.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovacular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Loh+M%22">Loh M</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lehne+B%22">Lehne B</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sotoodehnia+N%22">Sotoodehnia N</searchLink>; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Deary+IJ%22">Deary IJ</searchLink>; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Chadeau-Hyam+M%22">Chadeau-Hyam M</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Brody+JA%22">Brody JA</searchLink>; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cardona+A%22">Cardona A</searchLink>; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Selvin+E%22">Selvin E</searchLink>; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Smith+AK%22">Smith AK</searchLink>; Departments of Gynecology and Obstetrics & Psychiatry and Behavioral Science, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+AH%22">Miller AH</searchLink>; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Torres+MA%22">Torres MA</searchLink>; Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Marouli+E%22">Marouli E</searchLink>; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gào+X%22">Gào X</searchLink>; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22van+Meurs+JBJ%22">van Meurs JBJ</searchLink>; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Graf-Schindler+J%22">Graf-Schindler J</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Rathmann+W%22">Rathmann W</searchLink>; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Resesarch at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Koenig+W%22">Koenig W</searchLink>; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+A%22">Peters A</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weninger+W%22">Weninger W</searchLink>; Department of Dermatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Farlik+M%22">Farlik M</searchLink>; Department of Dermatology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Deptarment of Biostatistics, School of Public Health, Shandong University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Teumer+A%22">Teumer A</searchLink>; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Nauck+M%22">Nauck M</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Grabe+HJ%22">Grabe HJ</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Doerr+M%22">Doerr M</searchLink>; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lehtimäki+T%22">Lehtimäki T</searchLink>; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Guan+W%22">Guan W</searchLink>; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Milani+L%22">Milani L</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Tanaka+T%22">Tanaka T</searchLink>; Translational Gerontology Branch, Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+K%22">Fisher K</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Waite+LL%22">Waite LL</searchLink>; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kasela+S%22">Kasela S</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Vineis+P%22">Vineis P</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Verweij+N%22">Verweij N</searchLink>; Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Harst+P%22">van der Harst P</searchLink>; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Iacoviello+L%22">Iacoviello L</searchLink>; Department of Epidemiology and Prevention, IRCCS NEUROMED, Pozzilli, IS, Italy.; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese-Como, Italy.<br /><searchLink fieldCode="AU" term="%22Sacerdote+C%22">Sacerdote C</searchLink>; Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital and Centre for Cancer Prevention, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Panico+S%22">Panico S</searchLink>; Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Krogh+V%22">Krogh V</searchLink>; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tumino+R%22">Tumino R</searchLink>; Cancer Registry and Histopathology Department, 'Civic - MPP Arezzo' Hospital, ASP Ragusa, Ragusa, Italy.<br /><searchLink fieldCode="AU" term="%22Tzala+E%22">Tzala E</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Matullo+G%22">Matullo G</searchLink>; Department of Medical Sciences, University of Turin, Turin, Italy.; AOU Città della Salute e della Scienza di Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Hurme+MA%22">Hurme MA</searchLink>; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Raitakari+OT%22">Raitakari OT</searchLink>; Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Colicino+E%22">Colicino E</searchLink>; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Baccarelli+AA%22">Baccarelli AA</searchLink>; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kähönen+M%22">Kähönen M</searchLink>; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Herzig+KH%22">Herzig KH</searchLink>; Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu, and Oulu University Hospital, Oulu, Finland.; Department of Gastroenterology and Metabolism, Institute of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Conneely+KN%22">Conneely KN</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kooner+JS%22">Kooner JS</searchLink>; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.<br /><searchLink fieldCode="AU" term="%22Köttgen+A%22">Köttgen A</searchLink>; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Heijmans+BT%22">Heijmans BT</searchLink>; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Deloukas+P%22">Deloukas P</searchLink>; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Relton+C%22">Relton C</searchLink>; Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Ong+KK%22">Ong KK</searchLink>; MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bell+JT%22">Bell JT</searchLink>; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Elliott+P%22">Elliott P</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Imperial Biomedical Research Centre, Imperial College London, London, UK.; British Heart Foundation, BHF, Centre for Research Excellence, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Brenner+H%22">Brenner H</searchLink>; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Beekman+M%22">Beekman M</searchLink>; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Levy+D%22">Levy D</searchLink>; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Waldenberger+M%22">Waldenberger M</searchLink>; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Bavaria, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chambers+JC%22">Chambers JC</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Mandalay Road, Singapore, Singapore.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.<br /><searchLink fieldCode="AU" term="%22Dehghan+A%22">Dehghan A</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; UK Dementia Research Institute at Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Järvelin+MR%22">Järvelin MR</searchLink>; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. m.jarvelin@imperial.ac.uk.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Pentti Kaiteran katu 1, Linnanmaa, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland. m.jarvelin@imperial.ac.uk.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK. m.jarvelin@imperial.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 May 03; Vol. 13 (1), pp. 2408. <i>Date of Electronic Publication: </i>2022 May 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
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