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Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.

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Title: Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.
Authors: Milicaj J; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Hassan BA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Cote JM; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Ramirez-Mondragon CA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA., Jaunbocus N; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Rafalowski A; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Patel KR; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA., Castro CD; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Muthyala R; Department of Experimental and Clinical Pharmacology, College Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA., Sham YY; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu., Taylor EA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. eataylor@wesleyan.edu.
Source: Scientific reports [Sci Rep] 2022 May 04; Vol. 12 (1), pp. 7302. Date of Electronic Publication: 2022 May 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.
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  Data: <searchLink fieldCode="AU" term="%22Milicaj+J%22">Milicaj J</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Hassan+BA%22">Hassan BA</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Cote+JM%22">Cote JM</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez-Mondragon+CA%22">Ramirez-Mondragon CA</searchLink>; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Jaunbocus+N%22">Jaunbocus N</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Rafalowski+A%22">Rafalowski A</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Patel+KR%22">Patel KR</searchLink>; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Castro+CD%22">Castro CD</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA.<br /><searchLink fieldCode="AU" term="%22Muthyala+R%22">Muthyala R</searchLink>; Department of Experimental and Clinical Pharmacology, College Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA.<br /><searchLink fieldCode="AU" term="%22Sham+YY%22">Sham YY</searchLink>; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu.<br /><searchLink fieldCode="AU" term="%22Taylor+EA%22">Taylor EA</searchLink>; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. eataylor@wesleyan.edu.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2022 May 04; Vol. 12 (1), pp. 7302. <i>Date of Electronic Publication: </i>2022 May 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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