Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.
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| Title: | Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed. |
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| Authors: | Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Conomos MP; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Keener R; Department of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA., Iyer KR; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Weinstock JS; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA., Lane J; Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA., Miller-Fleming TW; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., McHugh CP; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Jain D; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Gogarten SM; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Laurie CA; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Keramati A; Department of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA., Arvanitis M; Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA., Smith AV; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Heavner B; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Barwick L; LTRC Data Coordinating Center, The Emmes Company, LLC, Rockville, MD, USA., Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Bleecker ER; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.; Division of Pharmacogenomics, University of Arizona, Tucson, AZ, USA., Burchard EG; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Celedón JC; Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Chang YPC; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., de las Fuentes L; Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., DeMeo DL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Garrett ME; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Gladwin MT; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Hidalgo BA; Department of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA., Irvin MR; Department of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA., Islam T; Division of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Johnson WC; Department of Biostatistics, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA., Kaab S; Department of Medicine I, University Hospital Munich, Ludwig-Maximilian's University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK); partner site: Munich Heart Alliance, Munich, Germany., Launer L; Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Lee J; Department of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Liu S; Department of Epidemiology and Brown Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA., Moscati A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Peyser PA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Rafaels N; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Seidman C; Genetics, Harvard Medical School, Boston, MA, USA., Weeks DE; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Wen F; Center for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA., Wheeler MM; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Williams LK; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Yang IV; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Zhao W; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Aslibekyan S; Department of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA., Auer PL; Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee WI, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Cade BE; Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen Z; Division of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; The National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Daya M; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Deka R; Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA., Eng C; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Fingerlin TE; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.; Department of Biostatistics and Informatics, University of Colorado Denver, Aurora, Colorado, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hou L; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Hwang SJ; Population Sciences Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD, USA., Johnsen JM; Bloodworks Northwest, Research Institute, Seattle, WA, USA.; University of Washington, Department of Medicine, Seattle, WA, USA., Kenny EE; Center for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA., Liu C; The National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Minster RL; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Naseri T; Ministry of Health, Government of Samoa, Apia, Samoa.; Department of Epidemiology & International Health Institute, School of Public Health, Brown University, Providence, USA., Nouraie M; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Reupena MS; Lutia i Puava ae Mapu i Fagalele, Apia, Samoa., Sabino EC; Instituto de Medicina Tropical da Faculdade de Medicina da Uiversidade de Sao Paulo, Sao Paulo, Brazil., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith NL; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Su JL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Taylor JG; Center for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA., Telen MJ; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.; Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA., Tiwari HK; Department of Biostatistics, University of Alabama Birmingham, Birmingham, AL, USA., Tracy RP; Departments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of Vermont, Colchester, VT, USA., White MJ; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Zhang Y; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vasan RS; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; The National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sinner MF; Department of Medicine I, University Hospital Munich, Ludwig-Maximilian's University, Munich, Germany.; German Centre for Cardiovascular Research (DZHK); partner site: Munich Heart Alliance, Munich, Germany., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Shoemaker MB; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Sciurba F; Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Schwartz DA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Roden D; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA., Redline S; Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Raby BA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Nekhai S; Center for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA., Montgomery CG; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Meyers DA; Department of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.; Division of Pharmacogenomics, University of Arizona, Tucson, AZ, USA., McGarvey ST; Department of Epidemiology & International Health Institute, School of Public Health, Brown University, Providence, USA., Mak AC; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Loos RJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn Schoold of Medicine at Mount Sinai, New York, NY, USA., Kumar R; Division of Allergy and Clinical Immunology, The Ann and Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics Northwestern University, Chicago, IL, USA., Kooperberg C; Division of Public Health Sciences, Fred Htutchinson Cancer Research Center, Seattle WA, USA., Konkle BA; Bloodworks Northwest, Research Institute, Seattle, WA, USA.; University of Washington, Department of Medicine, Seattle, WA, USA., Kelly S; Vitalant Research Institute, San Francisco, CA, USA.; UCSF Benioff Children's Hospital, Oakland, CA, USA., Kardia SL; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., He J; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA., Gui H; Center for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Gilliland FD; Division of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Gelb BD; Mindich Child Health and Development Institute, Departments of Pediatrics and Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Ellinor PT; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA., de Andrade M; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN,USA., Correa A; Jackson Heart Study and Departments of Medicine and Population Health Science, Jackson, MS, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Barnes KC; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Ashley-Koch AE; Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, USA., Laurie CC; Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Abecasis G; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MI, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Levy D; The National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.; The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA., Aviv A; Center of Human Development and Aging, Rutgers, New Jersey Medical School, Newark, NJ, USA., Blackwell TW; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Thornton T; Department of Biostatistics, University of Washington, Seattle, WA, USA., O'Connell J; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Cox NJ; Vanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Perry JA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Armanios M; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Battle A; Department of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA.; Departments of Computer Science and Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA., Pankratz N; Department of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Htutchinson Cancer Research Center, Seattle WA, USA., Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA. |
| Corporate Authors: | NHLBI CARE Network, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group |
| Source: | Cell genomics [Cell Genom] 2022 Jan 12; Vol. 2 (1). Date of Electronic Publication: 2022 Jan 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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