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Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.

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Title: Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.
Authors: Geng J; Zhongyuan District Center for Disease Control and Prevention of Zhengzhou, Zhengzhou, China., Hu X; Binzhou People's Hospital, Binzhou, Shandong Province, China., Zhang Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Gu Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Li Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Mou X; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Mao L; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Ge Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Yang X; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Song Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Liu H; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Wang L; Zhengzhou Key Laboratory of molecular biology, Zhengzhou Normal University, Zhengzhou, China., Wei Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Wang Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Xu H; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.
Source: Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4393-4405. Date of Electronic Publication: 2022 May 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1096-9071
DOI:10.1002/jmv.27853