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Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.

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Title: Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.
Authors: Geng J; Zhongyuan District Center for Disease Control and Prevention of Zhengzhou, Zhengzhou, China., Hu X; Binzhou People's Hospital, Binzhou, Shandong Province, China., Zhang Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Gu Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Li Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Mou X; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Mao L; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Ge Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Yang X; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Song Y; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China., Liu H; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Wang L; Zhengzhou Key Laboratory of molecular biology, Zhengzhou Normal University, Zhengzhou, China., Wei Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China., Wang Z; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China., Xu H; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.
Source: Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4393-4405. Date of Electronic Publication: 2022 May 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Geng+J%22">Geng J</searchLink>; Zhongyuan District Center for Disease Control and Prevention of Zhengzhou, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Binzhou People's Hospital, Binzhou, Shandong Province, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Gu+Z%22">Gu Z</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Mou+X%22">Mou X</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Mao+L%22">Mao L</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Ge+Y%22">Ge Y</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Zhengzhou Key Laboratory of molecular biology, Zhengzhou Normal University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+Z%22">Wei Z</searchLink>; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, China.; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, China.; Key Laboratory of 'Runliang' Antiviral Medicines Research and Development, Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.; Institute of Drug Discovery & Development, Zhengzhou University, Zhengzhou, China.
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  Data: <searchLink fieldCode="JN" term="%227705876%22">Journal of medical virology</searchLink> [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4393-4405. <i>Date of Electronic Publication: </i>2022 May 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7705876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201466615%22">01466615 </searchLink><i>NLM ISO Abbreviation: </i>J Med Virol <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1002/jmv.27853
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        Text: English
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        StartPage: 4393
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      – TitleFull: Discovery and pharmacodynamic evaluation of the novel butene lactone derivative M355 against influenza A virus in vitro and in vivo.
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              Text: 2022 Sep
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