SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.
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| Title: | SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity. |
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| Authors: | Zhang W; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Chua BY; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan., Selva KJ; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Kedzierski L; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, 3000, Australia., Ashhurst TM; Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia., Haycroft ER; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Shoffner-Beck SK; Department of Biomedical Engineering, University of Michigan, Michigan, USA., Hensen L; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Boyd DF; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., James F; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Mouhtouris E; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Kwong JC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia.; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Chua KYL; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Drewett G; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Copaescu A; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Dobson JE; Department of Radiology, Austin Health, Heidelberg, VIC, Australia., Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Habel JR; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Allen LF; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Koay HF; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Neil JA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Gartner MJ; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Lee CY; Department of Biomedical Engineering, University of Michigan, Michigan, USA., Andersson P; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Khan SF; Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia., Blakeway L; Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia., Wisniewski J; Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia., McMahon JH; Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, VIC, Australia.; Department of Infectious Diseases, Monash Medical Centre, Melbourne, VIC, Australia., Vine EE; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Sydney Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia., Cunningham AL; Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.; Sydney Infectious Diseases, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia., Audsley J; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia., Thevarajan I; Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.; Victorian Infectious Diseases Services, The Royal Melbourne Hospital and Doherty Department University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, 3000, VIC, Australia., Seemann T; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Sherry NL; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Londrigan SL; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Wakim LM; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., King NJC; Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, Australia.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.; Viral Immunopathology Laboratory, Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.; Sydney Nano, University of Sydney, Sydney, NSW, 2006, Australia., Godfrey DI; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Mackay LK; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Thomas PG; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA., Nicholson S; Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Arnold KB; Department of Biomedical Engineering, University of Michigan, Michigan, USA., Chung AW; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia., Holmes NE; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.; Department of Critical Care, University of Melbourne, Parkville, VIC, Australia.; Data Analytics Research and Evaluation (DARE) Centre, Austin Health and University of Melbourne, Heidelberg, VIC, Australia.; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia., Smibert OC; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia., Trubiano JA; Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia. trubianoj@unimelb.edu.au.; Department of Infectious Diseases, Peter McCallum Cancer Centre, Melbourne, VIC, Australia. trubianoj@unimelb.edu.au.; National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, VIC, Australia. trubianoj@unimelb.edu.au.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC, Australia. trubianoj@unimelb.edu.au., Gordon CL; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. claire.gordon@unimelb.edu.au.; Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia. claire.gordon@unimelb.edu.au., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. tho.nguyen@unimelb.edu.au., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, 3000, Australia. kkedz@unimelb.edu.au.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan. kkedz@unimelb.edu.au. |
| Source: | Nature communications [Nat Commun] 2022 May 19; Vol. 13 (1), pp. 2774. Date of Electronic Publication: 2022 May 19. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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