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The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.

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Title: The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.
Authors: Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Choi SW; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, NY, United States., Chami N; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, United States., Fornage M; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, United States., Redline S; Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.; Department of Epidemiology, University of Washington, Seattle, WA, United States., Kim W; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States., McDonald MN; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States., Regan EA; Division of Rheumatology, Department of Medicine, National Jewish Health, Denver, CO, United States., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States., Vasan RS; National Heart, Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, United States.; Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States.; Whitaker Cardiovascular Institute and Cardiology Section, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States., Kalyani RR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Mathias RA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Arnett DK; College of Public Health, University of Kentucky, Lexington, KY, United States., Justice AE; Department of Population Health Services, Geisinger Health, Danville, PA, United States., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, United States.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States., de Andrade M; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anchutz Medical Camus, Aurora, CA, United States., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States., Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States., Lubitz SA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, United States., Shoemaker MB; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, United States., Gladwin MT; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Albert CM; Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States., Chasman DI; Department of Medicine, Harvard Medical School, Boston, MA, United States.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States., Jackson RD; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, United States., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, United States.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States., O'Reilly PF; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, NY, United States., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 May 03; Vol. 13, pp. 863893. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1664-2392
DOI:10.3389/fendo.2022.863893