Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis.

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Title: Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis.
Authors: Zeng X; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.; Department of Neurology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China., Zhang YD; Department of Neurology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China., Ma RY; Department of Cardiovascular Surgery, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China., Chen YJ; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China., Xiang XM; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China., Hou DY; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China., Li XH; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China., Huang H; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China. 13708385559@163.com., Li T; State Key Laboratory of Trauma, Burns and Combined Injury, Department of Shock and Transfusion, Daping Hospital, Army Medical University, Chongqing, 400042, China. lt200132@126.com., Duan CY; Department of Anaesthesiology, the Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China. duanchenyang1991@cqmu.edu.cn.
Source: Military Medical Research [Mil Med Res] 2022 May 27; Vol. 9 (1), pp. 25. Date of Electronic Publication: 2022 May 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101643181 Publication Model: Electronic Cited Medium: Internet ISSN: 2054-9369 (Electronic) Linking ISSN: 20549369 NLM ISO Abbreviation: Mil Med Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2054-9369
DOI:10.1186/s40779-022-00383-2