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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.

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Title: A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Authors: Griffith DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Fortin JP; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Kuzmiski JB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Loria PM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Saxena AR; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Bagley SW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Buckeridge C; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Curto JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Derksen DR; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Dias JM; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Griffor MC; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Han S; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Jackson VM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Landis MS; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Lettiere D; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Limberakis C; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Liu Y; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Mathiowetz AM; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Patel JC; Sosei Heptares, Cambridge CB21 6DG, U.K., Piotrowski DW; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States., Price DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Ruggeri RB; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States., Tess DA; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8208-8226. Date of Electronic Publication: 2022 Jun 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
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  Data: <searchLink fieldCode="AU" term="%22Griffith+DA%22">Griffith DA</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Edmonds+DJ%22">Edmonds DJ</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Fortin+JP%22">Fortin JP</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kalgutkar+AS%22">Kalgutkar AS</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kuzmiski+JB%22">Kuzmiski JB</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Loria+PM%22">Loria PM</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Saxena+AR%22">Saxena AR</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Bagley+SW%22">Bagley SW</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Buckeridge+C%22">Buckeridge C</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Curto+JM%22">Curto JM</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Derksen+DR%22">Derksen DR</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dias+JM%22">Dias JM</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Griffor+MC%22">Griffor MC</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+VM%22">Jackson VM</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Landis+MS%22">Landis MS</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Lettiere+D%22">Lettiere D</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Limberakis+C%22">Limberakis C</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Mathiowetz+AM%22">Mathiowetz AM</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Patel+JC%22">Patel JC</searchLink>; Sosei Heptares, Cambridge CB21 6DG, U.K.<br /><searchLink fieldCode="AU" term="%22Piotrowski+DW%22">Piotrowski DW</searchLink>; Pfizer Worldwide Research, Development, and Medical, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Price+DA%22">Price DA</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Ruggeri+RB%22">Ruggeri RB</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Tess+DA%22">Tess DA</searchLink>; Pfizer Worldwide Research, Development, and Medical, Cambridge, Massachusetts 02139, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8208-8226. <i>Date of Electronic Publication: </i>2022 Jun 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.1c01856
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              Text: 2022 Jun 23
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