Delivery of an ectonucleotidase inhibitor with ROS-responsive nanoparticles overcomes adenosine-mediated cancer immunosuppression.
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| Title: | Delivery of an ectonucleotidase inhibitor with ROS-responsive nanoparticles overcomes adenosine-mediated cancer immunosuppression. |
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| Authors: | Mao C; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Yeh S; Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Fu J; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Porosnicu M; Depatment of Internal Medicine - Section of Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA., Thomas A; Depatment of Internal Medicine - Section of Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA., Kucera GL; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA., Votanopoulos KI; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA.; Department of Surgery - Section of Surgical Oncology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Tian S; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Ming X; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.; Comprehensive Cancer Center, Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2022 Jun 08; Vol. 14 (648), pp. eabh1261. Date of Electronic Publication: 2022 Jun 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.abh1261 |
