A ten-gene DNA-damage response pathway gene expression signature predicts gemtuzumab ozogamicin response in pediatric AML patients treated on COGAAML0531 and AAML03P1 trials.

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Title: A ten-gene DNA-damage response pathway gene expression signature predicts gemtuzumab ozogamicin response in pediatric AML patients treated on COGAAML0531 and AAML03P1 trials.
Authors: Gbadamosi MO; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Shastri VM; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Elsayed AH; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Ries R; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Olabige O; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Nguyen NHK; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., De Jesus A; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Wang YC; COG Statistics and Data Center, Monrovia, CA, USA., Dang A; COG Statistics and Data Center, Monrovia, CA, USA., Hirsch BA; University of Minnesota, Minneapolis, MN, USA., Alonzo TA; COG Statistics and Data Center, Monrovia, CA, USA.; Biostatistics Division, University of Southern California, Los Angeles, CA, USA., Gamis A; Department of Hematology-Oncology, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA., Meshinchi S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lamba JK; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA. jlamba@cop.ufl.edu.; Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville, FL, USA. jlamba@cop.ufl.edu.
Source: Leukemia [Leukemia] 2022 Aug; Vol. 36 (8), pp. 2022-2031. Date of Electronic Publication: 2022 Jun 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1476-5551
DOI:10.1038/s41375-022-01622-0