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Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial.

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Title: Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial.
Authors: Shaw RH; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Department of Infection, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: robert.shaw@paediatrics.ox.ac.uk., Liu X; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Stuart ASV; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Department of Infection, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Greenland M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Andrews NJ; Immunisation and Countermeasures Division, National Infection Service, UK Health Security Agency, London, UK; 3Statistics, Modelling and Economics Department, UK Health Security Agency, London, UK., Cameron JC; Public Health Scotland, Glasgow-Edinburgh, Scotland, UK., Charlton S; UK Health Security Agency, Porton Down, Salisbury, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Collins AM; Liverpool Vaccine Group, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dinesh T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Ferreira DM; Liverpool Vaccine Group, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Finn A; Bristol Vaccine Centre, Schools of Population Health Sciences and Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Green CA; NIHR-Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Hallis B; UK Health Security Agency, Porton Down, Salisbury, UK., Heath PT; The Vaccine Institute, St George's University of London, London, UK., Hill H; Liverpool Vaccine Group, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Lambe T; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK., Lazarus R; North Bristol NHS Trust, Bristol, UK., Libri V; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK., Long F; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Plested EL; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Morey ER; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Provstgaard-Morys S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Department of Infection, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Ramsay M; Immunisation and Countermeasures Division, National Infection Service, UK Health Security Agency, London, UK., Read RC; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK., Singh N; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Turner DPJ; School of Life Sciences, University of Nottingham, and Department of Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, UK., Turner PJ; National Heart & Lung Institute, Imperial College London, London, UK., Vichos I; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Walker LL; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., White R; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Nguyen-Van-Tam JS; Division of Epidemiology and Public Health, University of Nottingham School of Medicine, Nottingham, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Oxford NIHR-Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Corporate Authors: Com-COV Study Group
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2022 Nov; Vol. 10 (11), pp. 1049-1060. Date of Electronic Publication: 2022 Jun 09.
Publication Type: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial.
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Liverpool Vaccine Group, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lazarus+R%22">Lazarus R</searchLink>; North Bristol NHS Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Libri+V%22">Libri V</searchLink>; NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Long+F%22">Long F</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mujadidi+YF%22">Mujadidi YF</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Plested+EL%22">Plested EL</searchLink>; 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Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+H%22">Robinson H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Screaton+GR%22">Screaton GR</searchLink>; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Turner+DPJ%22">Turner DPJ</searchLink>; School of Life Sciences, University of Nottingham, and Department of Microbiology, Nottingham University Hospitals NHS Trust, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Turner+PJ%22">Turner PJ</searchLink>; National Heart & Lung Institute, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Vichos+I%22">Vichos I</searchLink>; 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