Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.
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| Title: | Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy. |
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| Authors: | Irvin SC; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America. susan.irvin@regeneron.com., D'Orvilliers A; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Bloch N; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Boccio K; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America., Pennucci J; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America.; EQRx, 50 Hampshire St, MA, 02139, Cambridge, United States of America., Brouwer-Visser J; Regeneron Pharmaceuticals, Precision Medicine, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Ullman E; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Rajadhyaksha M; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Alexion-AstraZeneca Rare Disease, 121 Seaport Blvd, MA, 02210, Boston, United States of America., Hassanein M; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Pfizer, Early Clinical Development, 445 Eastern Point Road, CT, 06340, Groton, United States of America., Potocky T; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Regeneron Pharmaceuticals, Research Project Management, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Torri A; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Hermann A; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Partridge MA; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America. |
| Source: | The AAPS journal [AAPS J] 2022 Jun 21; Vol. 24 (4), pp. 76. Date of Electronic Publication: 2022 Jun 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1550-7416 |
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| DOI: | 10.1208/s12248-022-00724-y |
