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Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.

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Title: Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.
Authors: Irvin SC; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America. susan.irvin@regeneron.com., D'Orvilliers A; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Bloch N; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Boccio K; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America., Pennucci J; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America.; EQRx, 50 Hampshire St, MA, 02139, Cambridge, United States of America., Brouwer-Visser J; Regeneron Pharmaceuticals, Precision Medicine, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Ullman E; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Rajadhyaksha M; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Alexion-AstraZeneca Rare Disease, 121 Seaport Blvd, MA, 02210, Boston, United States of America., Hassanein M; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Pfizer, Early Clinical Development, 445 Eastern Point Road, CT, 06340, Groton, United States of America., Potocky T; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Regeneron Pharmaceuticals, Research Project Management, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Torri A; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Hermann A; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America., Partridge MA; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.
Source: The AAPS journal [AAPS J] 2022 Jun 21; Vol. 24 (4), pp. 76. Date of Electronic Publication: 2022 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.
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  Data: <searchLink fieldCode="AU" term="%22Irvin+SC%22">Irvin SC</searchLink>; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America. susan.irvin@regeneron.com.<br /><searchLink fieldCode="AU" term="%22D'Orvilliers+A%22">D'Orvilliers A</searchLink>; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Bloch+N%22">Bloch N</searchLink>; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Boccio+K%22">Boccio K</searchLink>; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America.<br /><searchLink fieldCode="AU" term="%22Pennucci+J%22">Pennucci J</searchLink>; Immunologix Laboratories, 4710 Eisenhower Blvd, FL, 33634, Tampa, United States of America.; EQRx, 50 Hampshire St, MA, 02139, Cambridge, United States of America.<br /><searchLink fieldCode="AU" term="%22Brouwer-Visser+J%22">Brouwer-Visser J</searchLink>; Regeneron Pharmaceuticals, Precision Medicine, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Ullman+E%22">Ullman E</searchLink>; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Rajadhyaksha+M%22">Rajadhyaksha M</searchLink>; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Alexion-AstraZeneca Rare Disease, 121 Seaport Blvd, MA, 02210, Boston, United States of America.<br /><searchLink fieldCode="AU" term="%22Hassanein+M%22">Hassanein M</searchLink>; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Pfizer, Early Clinical Development, 445 Eastern Point Road, CT, 06340, Groton, United States of America.<br /><searchLink fieldCode="AU" term="%22Potocky+T%22">Potocky T</searchLink>; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.; Regeneron Pharmaceuticals, Research Project Management, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Torri+A%22">Torri A</searchLink>; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Hermann+A%22">Hermann A</searchLink>; Regeneron Pharmaceuticals, Therapeutic Proteins, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.<br /><searchLink fieldCode="AU" term="%22Partridge+MA%22">Partridge MA</searchLink>; Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, NY, 10591, Tarrytown, United States of America.
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      – TitleFull: Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy.
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