Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
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| Title: | Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate. |
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| Authors: | Freire MCLC; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Basso LGM; Physical Sciences Laboratory, State University of Northern Rio de Janeiro Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ, Brazil., Mendes LFS; Departament of Physics, Ribeirao Preto School of Philosophy, Science and Literature, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Mesquita NCMR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Mottin M; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Fernandes RS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Policastro LR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Godoy AS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Santos IA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil., Ruiz UEA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil., Caruso IP; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Sousa BKP; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Jardim ACG; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil., Almeida FCL; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center of Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Gil LHVG; Instituto Aggeu Magalhaes (IAM-FIOCRUZ), Recife, PE, Brazil., Andrade CH; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Oliva G; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil. oliva@ifsc.usp.br. |
| Source: | Scientific reports [Sci Rep] 2022 Jun 22; Vol. 12 (1), pp. 10601. Date of Electronic Publication: 2022 Jun 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-14790-x |
