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Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.

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Title: Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
Authors: Freire MCLC; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Basso LGM; Physical Sciences Laboratory, State University of Northern Rio de Janeiro Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ, Brazil., Mendes LFS; Departament of Physics, Ribeirao Preto School of Philosophy, Science and Literature, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Mesquita NCMR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Mottin M; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Fernandes RS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Policastro LR; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Godoy AS; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil., Santos IA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil., Ruiz UEA; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil., Caruso IP; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Sousa BKP; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Jardim ACG; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil., Almeida FCL; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center of Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Gil LHVG; Instituto Aggeu Magalhaes (IAM-FIOCRUZ), Recife, PE, Brazil., Andrade CH; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil., Oliva G; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil. oliva@ifsc.usp.br.
Source: Scientific reports [Sci Rep] 2022 Jun 22; Vol. 12 (1), pp. 10601. Date of Electronic Publication: 2022 Jun 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate.
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  Data: <searchLink fieldCode="AU" term="%22Freire+MCLC%22">Freire MCLC</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Basso+LGM%22">Basso LGM</searchLink>; Physical Sciences Laboratory, State University of Northern Rio de Janeiro Darcy Ribeiro (UENF), Campos dos Goytacazes, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendes+LFS%22">Mendes LFS</searchLink>; Departament of Physics, Ribeirao Preto School of Philosophy, Science and Literature, University of Sao Paulo, Ribeirao Preto, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Mesquita+NCMR%22">Mesquita NCMR</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Mottin+M%22">Mottin M</searchLink>; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+RS%22">Fernandes RS</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Policastro+LR%22">Policastro LR</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Godoy+AS%22">Godoy AS</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+IA%22">Santos IA</searchLink>; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.<br /><searchLink fieldCode="AU" term="%22Ruiz+UEA%22">Ruiz UEA</searchLink>; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.<br /><searchLink fieldCode="AU" term="%22Caruso+IP%22">Caruso IP</searchLink>; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+BKP%22">Sousa BKP</searchLink>; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.<br /><searchLink fieldCode="AU" term="%22Jardim+ACG%22">Jardim ACG</searchLink>; Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.; Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Sao Paulo State University (Unesp), Campus Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Almeida+FCL%22">Almeida FCL</searchLink>; Institute of Medical Biochemistry (IBqM) Leopoldo de Meis, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.; National Center of Nuclear Magnetic Resonance (CNRMN), Center of Structural Biology and Bioimaging (CENABIO), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Gil+LHVG%22">Gil LHVG</searchLink>; Instituto Aggeu Magalhaes (IAM-FIOCRUZ), Recife, PE, Brazil.<br /><searchLink fieldCode="AU" term="%22Andrade+CH%22">Andrade CH</searchLink>; Laboratory for Molecular Modeling and Drug Design, Labmol, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, GO, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliva+G%22">Oliva G</searchLink>; Institute of Physics of Sao Carlos, University of Sao Paulo, Sao Carlos, SP, Brazil. oliva@ifsc.usp.br.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2022 Jun 22; Vol. 12 (1), pp. 10601. <i>Date of Electronic Publication: </i>2022 Jun 22.
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